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Understanding Recurrent Pregnancy Loss: How Genetic Research Is Shaping the Future

Explore how new genetic research may help families experiencing recurrent pregnancy loss

In this conversation, Dr. Odelya Kaufman, a clinical geneticist and research scientist at Yale, discusses the RISE (Recurrent Pregnancy Loss Investigational Studies) project and how genetic research is advancing our understanding of recurrent pregnancy loss. She explains what recurrent pregnancy loss is, how it is evaluated today, and why many individuals still leave appointments without clear answers.

The discussion explores the known medical causes of recurrent pregnancy loss, including uterine differences, hormonal conditions, autoimmune disorders, and chromosomal abnormalities, while highlighting the significant number of cases that remain unexplained. Dr. Kaufman shares how whole genome sequencing is helping researchers investigate genetic factors beyond what current clinical testing can identify, with the goal of expanding knowledge and improving future care.

This resource may be especially meaningful for anyone searching for answers after multiple miscarriages, unexplained pregnancy loss, or wondering whether genetics may play a role in their fertility journey. It also provides practical information about participating in the RISE research study and what participants can expect from the research process.

While research cannot always provide immediate answers, every discovery brings the medical community one step closer to understanding experiences that have long remained unexplained.

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